4-Aryl-1,2-dithiole-3-thione derivatives are sulfur-containing heterocycles recognized for their broad-spectrum biological activities. In this study, two derivatives were synthesized via Field’s method (1955),1 and structurally characterized using FT-IR, 1H NMR, 13C NMR, and mass spectrometry. Their antimicrobial activity was assessed against selected bacterial and fungal strains using the disc diffusion method, as well as MIC and MBC assays. Both compounds exhibited significant antimicrobial effects, with the p–tolyl-substituted derivative demonstrating the best antifungal activity. Molecular docking studies, conducted with AutoDock Vina against representative bacterial and fungal protein targets, revealed favorable binding affinities and interaction profiles consistent with the experimental results.2,3These findings highlight the antimicrobial potential of the 1,2-dithiole-3-thione scaffold and support their further development as bioactive agents.
Acknowledgements: Brahimi Mohamed Habib gratefully acknowledges the ERASMUS program for providing funding support for the international PhD research stay at the “I+D de Fármacos ” research group, University of Santiago de Compostela.
