Laura Vázquez-Vázquez
CSO of BFlow

Atherosclerosis is a chronic inflammatory disease of the arterial vessels that is behind the main cardiovascular pathologies. Atherosclerosis is a complex multifactorial process, but the current cell culture models cannot reproduce all physiological conditions of human blood vessels. New in vitro advanced models are needed to test drugs targeting endothelial dysfunction and the formation of atherosclerotic plaques.

Vessel-on-a-chip models are able to reproduce relevant characteristics of human blood vessels, such as circular section, microvascular environment and physiological shear stress. In this work, we present three models that are designed to study the following characteristics:

The implementation and use of these models in the drug discovery process will allow:

  1. To reduce cost and time in the drug development process.
  2. To obtain data to rationally decide which drugs should be tested in clinical trials, reducing their failure rate.
  3. To reduce the use of experimental animal models.

SDDN poster